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Small tweaks.
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arokem committed Jun 11, 2024
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26 changes: 13 additions & 13 deletions poster.Rmd
Original file line number Diff line number Diff line change
Expand Up @@ -101,19 +101,19 @@ knitr::opts_chunk$set(echo = FALSE)
![](./images/Bar_Ilan_seal.svg.png){height=150 style="position: absolute; top: -50px; left: 2900px;"}


![](./images/qr_poster.png){height=200 style="position: absolute; top: 3800px; left: 2900px;"}
![](./images/qr_poster.png){height=260 style="position: absolute; top: 3800px; left: 2900px;"}


# Background

- Schizophrenia (SZ) is a neurodevelopmental psychiatric disorder that carries significant health burden.
- The *cognitive dysmetria* theory of schizophrenia posits that the core cognitive deficits arise from dysfunctions of cortical-thalamic-cerebellar (CTC) circuits. [@Andreasen1998-gg]
- Previous research found increased functional connectivity in the cerebello-thalamo-cortical circuits in individuals at clinical high risk for psychosis. [@Cao2018]
- Previous research found increased functional connectivity in CTC in individuals at clinical high risk for psychosis. [@Cao2018]
- This hyperconnectivity was more pronounced in individuals who converted to psychosis, correlated to the severity of symptoms, and was predictive of the time to conversion.
- The cerebellum sends its output through the superior cerebellar peduncle (SCP), the contralateral red nucleus (RN), and VA/VL of the thalamus to various cerebral areas. The decussation (d) of the cerebero-thalamo-cortical pathway is indicated by the yellow circle (image taken from [@Palesi2015-oi]).

<center>
![](images/palesi.jpg){width=60% height=60%}
![](images/palesi.png){width=60% height=60%}
</center>

**QUESTION**: Are the physical properties of the white matter tracts of the CTC different in individuals with SZ?
Expand Down Expand Up @@ -141,13 +141,13 @@ knitr::opts_chunk$set(echo = FALSE)
- Data quality confounds were mitigated by matching each SZ/ADHD/BD to a HC with similar age, sex and data quality (neighbor correlations, NDC).
- Generalized additive models (GAMs) for FA and MD in each SCP as [@Muncy2022GAMs]:
<p style="font-family:'Lucida Console', monospace">
FA/MD ~ group + s(nodeID, k, by=group) + \n age + sex + QC + s(subjectID, bs="re")
FA/MD ~ group + s(nodeID, k, by=group) + <br> &nbsp;&nbsp;&nbsp; age + sex + QC + s(subjectID, bs="re")
</p>
with k chosen to minimize AIC and neighbor correlations [@Yeh2019NDC] for QC.

# Acknowledgements
<div style="font-size:36px">
NIH grants: MH121867 (PI: Poldrack), MH121868 (PI: Rokem, EB027585 (PI: Garyfallidis)
NIH grants: MH121867 (PI: Poldrack), MH121868 (PI: Rokem), EB027585 (PI: Garyfallidis)
</div>

# Results{.mybreak}
Expand All @@ -164,9 +164,9 @@ NIH grants: MH121867 (PI: Poldrack), MH121868 (PI: Rokem, EB027585 (PI: Garyfall
</center>
<div style="font-size:32px; font-family:'Palatino'; text-align:center">Tract profiles of MD (left) and FA (right) $\pm$ bootstrapped 95% confidence interval</div>

- MD differed significantly in the left superior cerebellar peduncle (SCP) between the SZ and HC groups (p<0.05), but not between the ADHD and HC groups or BD and HC groups.
- Individuals with SZ had lower MD in this tract than the matched controls (as indicated).
- Individuals with SZ had lower MD in left superior cerebellar peduncle (SCP) than HC (p<0.05).
- This finding held after adding medication as a covariate (haloperidol equivalent dosage).
- No significant differences were found in FA or in other group comparisons.

# Conclusions

Expand All @@ -177,19 +177,19 @@ NIH grants: MH121867 (PI: Poldrack), MH121868 (PI: Rokem, EB027585 (PI: Garyfall

# Software

![](./images/qr_pyafq.png){height=260 style="position: absolute; top: 2875px; left: 1800px;"}
![](./images/qr_pyafq.png){height=260 style="position: absolute; top: 2750px; left: 1800px;"}
![](./images/qr_tractable.png){height=260 style="position: absolute; top: 3200px; left: 1800px;"}

<p style="margin-bottom:8cm">
<p style="margin-bottom:10cm">
**pyAFQ**: Automated Fiber Quantification / tractometry
</p>

![](./images/pyAFQ.png){height=300 style="position: absolute; top: 2875px; left: 2750px;"}
![](./images/pyAFQ.png){height=400 style="position: absolute; top: 2700px; left: 2750px;"}

<p style="margin-bottom:8cm">
**Tractable**: Statistical analysis tract profiles in R
<p style="margin-bottom:10cm">
**Tractable**: Statistical analysis of tract profiles in R
</p>
![](./images/cubic-spline-single.png){height=320 style="position: absolute; top: 3200px; left: 2700px;"}
![](./images/cubic-spline-single.png){height=420 style="position: absolute; top: 3200px; left: 2700px;"}

# References

26 changes: 13 additions & 13 deletions poster.html
Original file line number Diff line number Diff line change
Expand Up @@ -339,18 +339,18 @@ <h5 id="affiliation"><sup>1</sup> Department of Psychology and eScience Institut
<p><img src="images/W-Logo_White.png" style="position: absolute; top: 50px; left: 50px;" height="200" />
<img src="images/Block_S_2_color_red.png" style="position: absolute; top: 150px; left: 2920px;" height="150" />
<img src="images/Bar_Ilan_seal.svg.png" style="position: absolute; top: -50px; left: 2900px;" height="150" /></p>
<p><img src="images/qr_poster.png" style="position: absolute; top: 3800px; left: 2900px;" height="200" /></p>
<p><img src="images/qr_poster.png" style="position: absolute; top: 3800px; left: 2900px;" height="260" /></p>
<div id="background" class="section level1">
<h1>Background</h1>
<ul>
<li>Schizophrenia (SZ) is a neurodevelopmental psychiatric disorder that carries significant health burden.</li>
<li>The <em>cognitive dysmetria</em> theory of schizophrenia posits that the core cognitive deficits arise from dysfunctions of cortical-thalamic-cerebellar (CTC) circuits. <span class="citation">(<em>1</em>)</span></li>
<li>Previous research found increased functional connectivity in the cerebello-thalamo-cortical circuits in individuals at clinical high risk for psychosis. <span class="citation">(<em>2</em>)</span></li>
<li>Previous research found increased functional connectivity in CTC in individuals at clinical high risk for psychosis. <span class="citation">(<em>2</em>)</span></li>
<li>This hyperconnectivity was more pronounced in individuals who converted to psychosis, correlated to the severity of symptoms, and was predictive of the time to conversion.</li>
<li>The cerebellum sends its output through the superior cerebellar peduncle (SCP), the contralateral red nucleus (RN), and VA/VL of the thalamus to various cerebral areas. The decussation (d) of the cerebero-thalamo-cortical pathway is indicated by the yellow circle (image taken from <span class="citation">(<em>3</em>)</span>).</li>
</ul>
<center>
<img src="images/palesi.jpg" style="width:60.0%;height:60.0%" />
<img src="images/palesi.png" style="width:60.0%;height:60.0%" />
</center>
<p><strong>QUESTION</strong>: Are the physical properties of the white matter tracts of the CTC different in individuals with SZ?</p>
</div>
Expand Down Expand Up @@ -378,15 +378,15 @@ <h1>Methods</h1>
<li>Data quality confounds were mitigated by matching each SZ/ADHD/BD to a HC with similar age, sex and data quality (neighbor correlations, NDC).</li>
<li>Generalized additive models (GAMs) for FA and MD in each SCP as <span class="citation">(<em>7</em>)</span>:
<p style="font-family:&#39;Lucida Console&#39;, monospace">
FA/MD ~ group + s(nodeID, k, by=group) + age + sex + QC + s(subjectID, bs=“re”)
FA/MD ~ group + s(nodeID, k, by=group) + <br>     age + sex + QC + s(subjectID, bs=“re”)
</p>
with k chosen to minimize AIC and neighbor correlations <span class="citation">(<em>8</em>)</span> for QC.</li>
</ul>
</div>
<div id="acknowledgements" class="section level1">
<h1>Acknowledgements</h1>
<div style="font-size:36px">
<p>NIH grants: MH121867 (PI: Poldrack), MH121868 (PI: Rokem, EB027585 (PI: Garyfallidis)</p>
<p>NIH grants: MH121867 (PI: Poldrack), MH121868 (PI: Rokem), EB027585 (PI: Garyfallidis)</p>
</div>
</div>
<div id="results" class="section level1 mybreak">
Expand All @@ -406,9 +406,9 @@ <h1>Results</h1>
Tract profiles of MD (left) and FA (right) <span class="math inline">\(\pm\)</span> bootstrapped 95% confidence interval
</div>
<ul>
<li>MD differed significantly in the left superior cerebellar peduncle (SCP) between the SZ and HC groups (p&lt;0.05), but not between the ADHD and HC groups or BD and HC groups.</li>
<li>Individuals with SZ had lower MD in this tract than the matched controls (as indicated).</li>
<li>Individuals with SZ had lower MD in left superior cerebellar peduncle (SCP) than HC (p&lt;0.05).</li>
<li>This finding held after adding medication as a covariate (haloperidol equivalent dosage).</li>
<li>No significant differences were found in FA or in other group comparisons.</li>
</ul>
</div>
<div id="conclusions" class="section level1">
Expand All @@ -421,16 +421,16 @@ <h1>Conclusions</h1>
</div>
<div id="software" class="section level1">
<h1>Software</h1>
<p><img src="images/qr_pyafq.png" style="position: absolute; top: 2875px; left: 1800px;" height="260" />
<p><img src="images/qr_pyafq.png" style="position: absolute; top: 2750px; left: 1800px;" height="260" />
<img src="images/qr_tractable.png" style="position: absolute; top: 3200px; left: 1800px;" height="260" /></p>
<p style="margin-bottom:8cm">
<p style="margin-bottom:10cm">
<strong>pyAFQ</strong>: Automated Fiber Quantification / tractometry
</p>
<p><img src="images/pyAFQ.png" style="position: absolute; top: 2875px; left: 2750px;" height="300" /></p>
<p style="margin-bottom:8cm">
<strong>Tractable</strong>: Statistical analysis tract profiles in R
<p><img src="images/pyAFQ.png" style="position: absolute; top: 2700px; left: 2750px;" height="400" /></p>
<p style="margin-bottom:10cm">
<strong>Tractable</strong>: Statistical analysis of tract profiles in R
</p>
<p><img src="images/cubic-spline-single.png" style="position: absolute; top: 3200px; left: 2700px;" height="320" /></p>
<p><img src="images/cubic-spline-single.png" style="position: absolute; top: 3200px; left: 2700px;" height="420" /></p>
</div>
<div id="references" class="section level1 unnumbered">
<h1>References</h1>
Expand Down
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