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Copy pathNM_001159694.gb
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NM_001159694.gb
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LOCUS NM_001159694 3927 bp mRNA linear PRI 18-DEC-2022
DEFINITION Homo sapiens endomucin (EMCN), transcript variant 2, mRNA.
ACCESSION NM_001159694
VERSION NM_001159694.2
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3927)
AUTHORS Wang S, Jin J, Chen J and Lou W.
TITLE MUC14-Related ncRNA-mRNA Network in Breast Cancer
JOURNAL Genes (Basel) 12 (11), 1677 (2021)
PUBMED 34828282
REMARK GeneRIF: MUC14-Related ncRNA-mRNA Network in Breast Cancer.
Publication Status: Online-Only
REFERENCE 2 (bases 1 to 3927)
AUTHORS Hu Z, Cano I, Saez-Torres KL, LeBlanc ME, Saint-Geniez M, Ng YS,
Argueso P and D'Amore PA.
TITLE Elements of the Endomucin Extracellular Domain Essential for
VEGF-Induced VEGFR2 Activity
JOURNAL Cells 9 (6), 1413 (2020)
PUBMED 32517158
REMARK GeneRIF: Elements of the Endomucin Extracellular Domain Essential
for VEGF-Induced VEGFR2 Activity.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 3927)
AUTHORS Yang J, LeBlanc ME, Cano I, Saez-Torres KL, Saint-Geniez M, Ng YS
and D'Amore PA.
TITLE ADAM10 and ADAM17 proteases mediate proinflammatory
cytokine-induced and constitutive cleavage of endomucin from the
endothelial surface
JOURNAL J Biol Chem 295 (19), 6641-6651 (2020)
PUBMED 32193206
REMARK GeneRIF: ADAM10 and ADAM17 proteases mediate proinflammatory
cytokine-induced and constitutive cleavage of endomucin from the
endothelial surface.
REFERENCE 4 (bases 1 to 3927)
AUTHORS Reckzeh K, Kizilkaya H, Helbo AS, Alrich ME, Deslauriers AG, Grover
A, Rapin N, Asmar F, Gronbaek K, Porse B, Borregaard N, Vestweber
D, Nerlov C and Theilgaard-Monch K.
TITLE Human adult HSCs can be discriminated from lineage-committed HPCs
by the expression of endomucin
JOURNAL Blood Adv 2 (13), 1628-1632 (2018)
PUBMED 29986855
REMARK GeneRIF: Human adult HSCs can be discriminated from
lineage-committed HPCs by the expression of endomucin.
REFERENCE 5 (bases 1 to 3927)
AUTHORS Iftakhar-E-Khuda I, Fair-Makela R, Kukkonen-Macchi A, Elima K,
Karikoski M, Rantakari P, Miyasaka M, Salmi M and Jalkanen S.
TITLE Gene-expression profiling of different arms of lymphatic
vasculature identifies candidates for manipulation of cell traffic
JOURNAL Proc Natl Acad Sci U S A 113 (38), 10643-10648 (2016)
PUBMED 27601677
REMARK GeneRIF: In contrast, endomucin (EMCN) is present on the lymphatic
sinus endothelium and not on lymphatic endothelium of the
subcapsular sinus. Moreover, both murine and human MSR1 on
lymphatic endothelium of the SS bind lymphocytes and in in vivo
studies MSR1 regulates entrance of lymphocytes from the SS to the
lymph node parenchyma
REFERENCE 6 (bases 1 to 3927)
AUTHORS Kanda H, Tanaka T, Matsumoto M, Umemoto E, Ebisuno Y, Kinoshita M,
Noda M, Kannagi R, Hirata T, Murai T, Fukuda M and Miyasaka M.
TITLE Endomucin, a sialomucin expressed in high endothelial venules,
supports L-selectin-mediated rolling
JOURNAL Int Immunol 16 (9), 1265-1274 (2004)
PUBMED 15249540
REFERENCE 7 (bases 1 to 3927)
AUTHORS Kuhn A, Brachtendorf G, Kurth F, Sonntag M, Samulowitz U, Metze D
and Vestweber D.
TITLE Expression of endomucin, a novel endothelial sialomucin, in normal
and diseased human skin
JOURNAL J Invest Dermatol 119 (6), 1388-1393 (2002)
PUBMED 12485444
REFERENCE 8 (bases 1 to 3927)
AUTHORS Samulowitz U, Kuhn A, Brachtendorf G, Nawroth R, Braun A, Bankfalvi
A, Bocker W and Vestweber D.
TITLE Human endomucin: distribution pattern, expression on high
endothelial venules, and decoration with the MECA-79 epitope
JOURNAL Am J Pathol 160 (5), 1669-1681 (2002)
PUBMED 12000719
REFERENCE 9 (bases 1 to 3927)
AUTHORS Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston
E and Nguyen M.
TITLE Human endomucin is an endothelial marker
JOURNAL Biochem Biophys Res Commun 288 (1), 129-136 (2001)
PUBMED 11594763
REFERENCE 10 (bases 1 to 3927)
AUTHORS Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K
and Noda M.
TITLE Identification of human endomucin-1 and -2 as membrane-bound
O-sialoglycoproteins with anti-adhesive activity
JOURNAL FEBS Lett 499 (1-2), 121-126 (2001)
PUBMED 11418125
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BG506923.1, AK304568.1, AK291831.1, AC097459.3 and AL133118.1.
On May 31, 2019 this sequence version replaced NM_001159694.1.
Summary: EMCN is a mucin-like sialoglycoprotein that interferes
with the assembly of focal adhesion complexes and inhibits
interaction between cells and the extracellular matrix (Kinoshita
et al., 2001 [PubMed 11418125]).[supplied by OMIM, Mar 2008].
Transcript Variant: This variant (2) lacks an in-frame exon in the
middle portion of the coding region compared to variant 1. This
results in a shorter protein (isoform 2) compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK304568.1, DRR138524.1354.1
[ECO:0000332]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-21 BG506923.1 73-93
22-1259 AK304568.1 3-1240
1260-1379 AK291831.1 1031-1150
1380-3172 AC097459.3 25700-27492 c
3173-3927 AL133118.1 1482-2236
FEATURES Location/Qualifiers
source 1..3927
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4q24"
gene 1..3927
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/note="endomucin"
/db_xref="GeneID:51705"
/db_xref="HGNC:HGNC:16041"
/db_xref="MIM:608350"
exon 1..172
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/inference="alignment:Splign:2.1.0"
CDS 109..855
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/note="isoform 2 precursor is encoded by transcript
variant 2; endomucin-2; MUC-14; mucin-14; gastric cancer
antigen Ga34"
/codon_start=1
/product="endomucin isoform 2 precursor"
/protein_id="NP_001153166.1"
/db_xref="CCDS:CCDS54782.1"
/db_xref="GeneID:51705"
/db_xref="HGNC:HGNC:16041"
/db_xref="MIM:608350"
/translation="MELLQVTILFLLPSICSSNSTGVLEAANNSLVVTTTKPSITTPN
TESLQKNVVTPTTGTTPKGTITNELLKMSLMSTATFLTSKDEGLKATTTDVRKNDSII
SNVTVTSVTLPNAVSTLQSSKPKSSVLQPDASPSKTGTLTSIPVTIPENTSQSQVIGT
EGGKNASTSATSRSYSSIILPVVIALIVITLSVFVLVGLYRMCWKADPGTPENGNDQP
QSDKESVKLLTVKTISHESGEHSAQGKTKN"
sig_peptide 109..162
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
exon 173..295
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/inference="alignment:Splign:2.1.0"
exon 296..367
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/inference="alignment:Splign:2.1.0"
exon 368..484
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/inference="alignment:Splign:2.1.0"
exon 485..577
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/inference="alignment:Splign:2.1.0"
exon 578..637
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/inference="alignment:Splign:2.1.0"
exon 638..733
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/inference="alignment:Splign:2.1.0"
exon 734..758
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/inference="alignment:Splign:2.1.0"
exon 759..820
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/inference="alignment:Splign:2.1.0"
exon 821..894
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/inference="alignment:Splign:2.1.0"
exon 895..3927
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/inference="alignment:Splign:2.1.0"
regulatory 3787..3792
/regulatory_class="polyA_signal_sequence"
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/note="hexamer: ATTAAA"
polyA_site 3812
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/note="major polyA site"
regulatory 3892..3897
/regulatory_class="polyA_signal_sequence"
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/note="hexamer: AATAAA"
polyA_site 3927
/gene="EMCN"
/gene_synonym="EMCN2; MUC14"
/note="major polyA site"
ORIGIN
1 acattcacta caccttttcc atttgctaat aaggccctgc caggctggga gggaattgtc
61 cctgcctgct tctggagaaa gaagatattg acaccatcta cgggcaccat ggaactgctt
121 caagtgacca ttctttttct tctgcccagt atttgcagca gtaacagcac aggtgtttta
181 gaggcagcta ataattcact tgttgttact acaacaaaac catctataac aacaccaaac
241 acagaatcat tacagaaaaa tgttgtcaca ccaacaactg gaacaactcc taaaggaaca
301 atcaccaatg aattacttaa aatgtctctg atgtcaacag ctactttttt aacaagtaaa
361 gatgaaggat tgaaagccac aaccactgat gtcaggaaga atgactccat catttcaaac
421 gtaacagtaa caagtgttac acttccaaat gctgtttcaa cattacaaag ttccaaaccc
481 aagagtagtg ttctacaacc agatgcatca ccttctaaaa ctggtacatt aacctcaata
541 ccagttacaa ttccagaaaa cacctcacag tctcaagtaa taggcactga gggtggaaaa
601 aatgcaagca cttcagcaac cagccggtct tattccagta ttattttgcc ggtggttatt
661 gctttgattg taataacact ttcagtattt gttctggtgg gtttgtaccg aatgtgctgg
721 aaggcagatc cgggcacacc agaaaatgga aatgatcaac ctcagtctga taaagagagc
781 gtgaagcttc ttaccgttaa gacaatttct catgagtctg gtgagcactc tgcacaagga
841 aaaaccaaga actgacagct tgaggaattc tctccacacc taggcaataa ttacgcttaa
901 tcttcagctt ctatgcacca agcgtggaaa aggagaaagt cctgcagaat caatcccgac
961 ttccatacct gctgctggac tgtaccagac gtctgtccca gtaaagtgat gtccagctga
1021 catgcaataa tttgatggaa tcaaaaagaa ccccggggct ctcctgttct ctcacattta
1081 aaaattccat tactccattt acaggagcgt tcctaggaaa aggaatttta ggaggagaat
1141 ttgtgagcag tgaatctgac agcccaggag gtgggctcgc tgataggcat gactttcctt
1201 aatgtttaaa gttttccggg ccaagaattt ttatccatga agactttcct acttttctca
1261 gtgttcttat attacctact gttagtattt attgtttacc actatgttaa tgcagggaaa
1321 agttgcacgt gtattattaa atattaggta gaaatcatac catgctactt tgtacatata
1381 agtattttat tcctgctttc gtgttacttt taataaataa ctactgtact caatactcta
1441 aaaatactat aacatgactg tgaaaatggc aatgttattg tcttcctata attatgaata
1501 tttttggatg gattattaga atacatgaac tcactaatga aaggcatttg taataagtca
1561 gaaagggaca tacgattcac atatcagact gttaggggga gagtaattta tcagttcttt
1621 ggtctttcta tttgtcattc atactatgtg atgaagatgt aagtgcaagg gcatttataa
1681 cactatactg cattcattaa gataatagga tcatgatttt tcattaactc atttgattga
1741 tattatctcc atgcattttt tatttctttt agaaatgtaa ttatttgctc tagcaatcat
1801 tgctaacctc tagtttgtag aaaatcaaca ctttataaat acataattat gatattattt
1861 ttcattgtat cactgttcta aaaataccat atgattatag ctgccactcc atcaggagca
1921 aattcttctg ttaaaagcta actgatcaac cttgaccact tttttgacat gtgagatcaa
1981 agtgtcaagt tggctgaggt tttttggaaa gctttagaac taataagctg ctggtggcag
2041 ctttgtaacg tatgattatc taagctgatt ttgatgctaa attatcttag tgatctaagg
2101 ggcagtttag tgaagatgga atcttgtatt taaaatagcc ttttaaaatt tgttttgtgg
2161 tgatgtattt tgacaacttc catctttagg agttatataa tcaccttgat tttagtttcc
2221 tgatgtttgg actatttata atcaaggaca ccaagcaagc ataagcatat ctatatttct
2281 gactggtgtc tctttgagaa ggatgggaag tagaaaaaaa aaaaagaaag aaaggaaagg
2341 aagagaggag agaagaaggc agggatctcc actatgtatg ttttcacttt agaactgttg
2401 agcccatgct taattttaat ctagaagtct ttaaatggtg agacagtgac tggagcatgc
2461 caatcagaga gcatttgtct tcagaaaaaa aaaaaatctg agtttgagac tagcctggcc
2521 aacatgttga aaccccatat ctactaaaaa tacaaaaatt agcctggtgt ggtggcgcac
2581 gcctgtagtc ccagctactc tggagcctga ggaacgtgaa tcgcttgaac ccagaagaca
2641 gaggttgcag tgagctgaga tggcactatt gcactccagc ctgggtgaca cagcaagact
2701 ctgtctcaaa aaaaaaaaaa aaaaaaagga aaaaaaagaa agaaagaaag tcccagcaca
2761 cctagataat ttaccgagct cttcagcaaa aaccatgtta catacagcat attccaaaga
2821 aatgaactct tctgcaattt aaattataag taatatgtta ttttggatcc tagagaaacc
2881 attttctcta catttcatga gcatggttag aaaagagttt acaagaatta ggaagaggga
2941 acaattttaa tggtcagaaa agaataaaat ttattctagt tcaagaagtg cacacaaaga
3001 atatgcatta atctaacaac tatgagatta aatctttcaa aaaggtcaaa ggaggattga
3061 gaagtttaca gagatgtcca cggcatttta tatcaatctc aaaggtaagg tctgcatttt
3121 tataaaccaa cttaaacttc tgttgagata ggatattttg ttttcaagcc aaaattacca
3181 ttaatcaaat atgttttaat tatctgattt agatgatcta ctttttatgc ctggcttact
3241 gtaagttttt tattctgata cacagttcaa acatcattgc aacaaagaag tgcctgtatt
3301 tagatcaaag gcaagacttt ctatgtgttt gttttgcata ataatatgaa tataatttaa
3361 gtctatcaat agtcaaaaca taaacaaaag ctaattaact ggcactgttg tcacctgaga
3421 ctaagtggat gttgttggct gacatacagg ctcagccagc agagaaagaa ttctgaattc
3481 cccttgctga actgaactat tctgttacat atggttgaca aatctgtgtg ttatttcttt
3541 tctacctacc atatttaaat ttatgagtat caaccgagga catagtcaaa ccttcgatga
3601 tgaacattcc tgattttttg cctgattatt ctctgttgag ctctacttgt ggtcattcaa
3661 gattttatga tgttgaaagg aaaagtgaat atgaccttta aaaattgtat tttgggtgat
3721 gatagtctca ccactataaa actgtcaatt attgcctaat gttaaagata tccatcattg
3781 tgattaatta aacctataat gagtattctt aatggagaat tcttaatgga tggattatcc
3841 cctgatcttt tctttaaaat ttctctgcac acacaggact tctcattttc caataaatgg
3901 gtgtactctg ccccaatttc tagggaa
//